DNA polymerase epsilon catalytic subunit is an enzyme that in humans is encoded by the POLE gene. It is the central catalytic subunit of DNA polymerase epsilon.

Clinical significance

POLE, along with POLD1, has in 2013 been associated with multiple adenoma.

Interactions

POLE has been shown to interact with RAD17.

References

Further reading



POLE Mutations and Endometrial Cancer Castrillon Lab UT

POLE gene hotspot mutations in advanced pancreatic cancer Request PDF

POLE Gene GeneCards DPOE1 Protein DPOE1 Antibody

Mutation points of the polE gene in three different S strains

Multigene model demonstrates that POLE is predictive of improved